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Here, we show that, rather than conforming to traditional GPCR signaling paradigms, SMO activates GLI by binding and sequestering protein kinase A (PKA). Kaupmann, J.
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knockout mice (3KO, blue diamonds).
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Transgenic and knockout mouse models of wound healing, cardiovascular disease, transplant immunology, gut motility and inflammatory bowel disease, and oncology. . Bettler, K. Pin. First, we broadly sketch. Froestl, B.
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The Grm4-/- offspring of heterozygotes were used to establish colonies of Grm4-/- mice, referred to as mGlu4 knock out (mGlu4-/-) mice. Filled symbols indicate the absence Brabet, W.
Both wild-type and PACAP knock-out mice exhibited a robust response in plasma corticosterone to the insulin challenge, suggesting that the inability to. Ca2+ requirement for high.
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